Preclinical is not clinical — GATC-1021 has not treated a single human patient. But the structural failure here precedes any regulatory hurdle: a compound targeting one of America's most lethal public health conditions, derived using the AI methods that research communities spend enormous energy debating, arrived in those same communities and disappeared. The rather than opioid receptors directly — a design choice that AI-platform analysis made possible by scanning receptor interaction space at a scale beyond manual chemistry. That methodological fact alone should have anchored…